Sirtuins

A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

Also Known As:

SIRTs; Silent Mating Type Information Regulator 2-like Proteins; Silent Mating Type Information Regulator 2 like Proteins; Sir2 like Proteins; SIRT; Sir2-like Proteins; Sirtuin

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Glycosyltransferases: 802
      - Pentosyltransferases
        ADP Ribose Transferases: 204
        Sirtuins: 2388
  - Hydrolases: 2206
    - Amidohydrolases: 43
      - Histone Deacetylases: 5289
        Group III Histone Deacetylases: 14
        Sirtuins: 2388
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intracellular Signaling Peptides and Proteins: 32
    - Sirtuins: 2388

Ying-Ling Chiang Selected Research

Ying-Ling Chiang Research Topics

Disease

Drug/Important Bio-Agent (IBA)